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Pneumococcal conjugate vaccine (PCV) efficacy is lower for noninvasive pneumonia than invasive disease. In this study, participants were immunized with 13-valent PCV (PCV13) or hepatitis A vaccine (control). Bronchoalveolar lavage samples were taken between 2 and 6 months and serum at 4 and 7 weeks postvaccination. In the lung, anti-capsular immunoglobulin G (IgG) levels were higher in the PCV13 group compared to controls for all serotypes, except 3 and 6B. Systemically, IgG levels were elevated in the PCV13 group at 4 weeks for all serotypes, except serotype 3. IgG in bronchoalveolar lavage and serum positively correlated for nearly all serotypes. PCV13 shows poor immunogenicity to serotype 3, implying lack of protective efficacy. Clinical Trials Registration. ISRCTN 45340436.

Original publication

DOI

10.1093/infdis/jiab331

Type

Journal article

Journal

J Infect Dis

Publication Date

04/05/2022

Volume

225

Pages

1626 - 1631

Keywords

BAL, PCV13, anti-capsular IgG, pneumococcus, Antibodies, Bacterial, Humans, Immunoglobulin G, Infant, Lung, Pneumococcal Infections, Pneumococcal Vaccines, Serogroup, Vaccines, Conjugate