Outcomes in Children With Enterovirus Meningitis in London, England: A Retrospective Multicenter Cohort Study, 2013-2023.
Broad J., Zombori L., Bravo Queipo-de-Llano B., Bamford A., Best T., Cohen J., Drysdale SB., Manian A., Soni N., Whittaker E., Kadambari S.
Nonpolio enteroviruses are the most common cause of meningitis in children. We conducted a retrospective case series of long-term outcomes in 243 children between 1 January 2013 and 31 December 2023 across 4 tertiary centers in London. Adverse outcomes were associated with the absence of fever at presentation (odds ratio [OR], 4.65; 95% CI, 1.03-20.83), the presence of seizures (OR, 7.40; 95% CI, 1.05-51.96), and the presence of comorbidities at baseline (OR, 5.27; 95% CI, 1.18-23.47). Full recovery was seen in 153 of 160 (95.6%) children who were <3 months of age. These data may help clinicians to counsel parents and policy makers on streamlining care pathways following hospital discharge.