Declining Antibody Affinity Over Time After Human Vaccination With a Plasmodium falciparum Merozoite Vaccine Candidate.
Persson KEM., Horton JL., Kurtovic L., McCarthy JS., Anders RF., Beeson JG.
UNLABELLED: Maintaining high-affinity antibodies after vaccination may be important for long-lasting immunity to malaria, but data on induction and kinetics of affinity is lacking. In a phase 1 malaria vaccine trial, antibody affinity increased following a second vaccination but declined substantially over 12 months, suggesting poor maintenance of high-affinity antibodies. CLINICAL TRIALS REGISTRATION: Australian New Zealand Clinical Trials Registry ACTRN12607000552482.