Daniel O'Connor
BSc AFHEA MSc DPhil (OXON)
Associate Professor | Head of Bioinformatics
Daniel has both a wet-laboratory and bioinformatics background, his main research interests relate to the analysis of contemporary, high-dimensional datasets (e.g. genomic, transcriptomic, proteomic) to elucidate the molecular determinants of vaccine responses.
UTILISING THE SYSTEMS TOOLKIT TO ELUCIDATE THE MECHANISMS UNDERLYING RESPONSES TO INFANT IMMUNISATION
Vaccine responses and the persistence of vaccine-immunity vary considerably between individuals, this is particularly relevant in childhood, as infants generally have lower magnitude immune responses that wane more rapidly than adults. My research utilises contemporary methods, such as genome-wide genotyping and next-generation sequencing, to explore the mechanisms underlying immunological and physiological responses to childhood vaccinations.
Key publications
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Human leukocyte antigen alleles associate with COVID-19 vaccine immunogenicity and risk of breakthrough infection.
Journal article
Mentzer AJ. et al, (2023), Nat Med, 29, 147 - 157
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Molecular correlates of vaccine-induced protection against typhoid fever.
Journal article
Zhu H. et al, (2023), J Clin Invest, 133
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Gene expression profiling reveals insights into infant immunological and febrile responses to group B meningococcal vaccine.
Journal article
O'Connor D. et al, (2020), Mol Syst Biol, 16
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Common Genetic Variations Associated with the Persistence of Immunity following Childhood Immunization
Journal article
O'Connor D. et al, (2019), Cell Reports
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RNA2HLA: HLA-based quality control of RNA-seq datasets
Journal article
Chelysheva I. et al, (2021), Briefings in Bioinformatics
Recent publications
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Targeted metagenomics reveals association between severity and pathogen co-detection in infants with respiratory syncytial virus.
Journal article
Lin G-L. et al, (2024), Nat Commun, 15
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Plasma Protein Biomarkers Distinguish Multisystem Inflammatory Syndrome in Children From Other Pediatric Infectious and Inflammatory Diseases.
Journal article
Yeoh S. et al, (2024), Pediatr Infect Dis J
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Discovery and validation of plasma-based protein biomarkers for the aetiological distinction of bacterial and non-bacterial febrile infections in African children
Preprint
Waeni JM. et al, (2024)
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Spotlight on systems vaccinology: a novel approach to elucidate correlates of protection.
Journal article
Zhu H. et al, (2023), Genes Immun
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Cellular and Transcriptional Signature of the Nasal Mucosa is Associated with Susceptibility to Pneumococcal Carriage in Older Adults
Preprint
Urban BC. et al, (2023)