AZD1222/ChAdOx1 nCoV-19 vaccination induces a polyfunctional spike protein-specific Th1 response with a diverse TCR repertoire.

Swanson PA., Padilla M., Hoyland W., McGlinchey K., Fields PA., Bibi S., Faust SN., McDermott AB., Lambe T., Pollard AJ., Durham NM., Kelly EJ., AstraZeneca/Oxford/VRC Study Group None., Adlou S., Aley PK., Angus B., Anslow R., Baker P., Bansal H., Beveridge A., Bridges-Webb A., Ching S., Cicconi P., Clutterbuck EA., Collins AM., Darton TC., Demissie T., Dinesh T., Douglas AD., Duncan CJA., Ewer KJ., Felle S., Ferreira DM., Folegatti PM., Fuskova M., Gaudinski M., Gilbert SC., Goodman AL., Gordon I., Green CA., Harbolick E., Hayes S., Hill AVS., Hill H., Jenkin D., Jepson BM., Kasanyinga M., Libri V., Lillie PJ., McGregor AC., Minassian AM., Mujadidi YF., Novik L., Payne R., Pilataxi F., Plested E., Provstgaard-Morys S., Ramasamy M., Robinson H., Sanders K., Smith A., Snape MD., Song R., Sutherland RK., Thomson EC., Toshner M., Turner DPJ., Voysey M., Widge AT., Williams CJ.

[Figure: see text].

DOI

10.1126/scitranslmed.abj7211

Type

Journal article

Journal

Science translational medicine

Publication Date

30/09/2021

Pages

eabj7211 - eabj7211

Addresses

Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Keywords

AstraZeneca/Oxford/VRC Study Group

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