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Paradoxical reactions in central nervous system tuberculosis (CNS-TB) are associated with significant morbidity and mortality. We describe 4 HIV-uninfected children treated for CNS-TB with severe paradoxical reactions unresponsive to corticosteroids. All made recovery after treatment with infliximab, highlighting the safety and effectiveness of infliximab for this complication, and need for prospective trials.

Original publication

DOI

10.1093/jpids/piab094

Type

Journal article

Journal

J Pediatric Infect Dis Soc

Publication Date

05/10/2021

Keywords

central nervous system tuberculosis, infliximab, paradoxical reaction, tuberculous meningitis