Immune responses in children after vaccination with a typhoid Vi-tetanus toxoid conjugate vaccine in Bangladesh.

Khanam F., Babu G., Rahman N., Liu X., Rajib NH., Ahmed SU., Hossen MI., Biswas PK., Kelly S., Thesis-Nyland K., Mujadidi Y., McMillan NAJ., Pollard AJ., Clemens JD., Qadri F.

A cluster-randomized trial of Vi-TT was conducted in Dhaka, Bangladesh, using JE vaccine as the control. A subset of 1,500 children were randomly selected on 2:1 basis (Vi-TT vs JE) to assess immune response. Blood was collected before vaccination, and on days 28, 545 and 730 post-vaccination and plasma anti-Vi-IgG response was measured. A robust, persistent antibody response was induced after single dose of Vi-TT, even after 2 years of vaccination. While there is no accepted serological antibody threshold of protection, analyzing the antibodies of children who received Vi-TT provides evidence that may later be useful in predicting population protection.

DOI

10.1016/j.vaccine.2023.04.014

Type

Journal article

Journal

Vaccine

Publication Date

05/05/2023

Volume

41

Pages

3137 - 3140

Keywords

Bangladeshi children, CRT-TCV, Long-term immune response, Humans, Child, Typhoid Fever, Tetanus Toxoid, Salmonella typhi, Vaccines, Conjugate, Bangladesh, Immunoglobulin G, Typhoid-Paratyphoid Vaccines, Antibodies, Bacterial, Vaccination, Antibody Formation

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