Russell N., Hatcher J., Best T., Breuer J., Charlesworth J., Muir P., Vipond B., Paulus S., Saxena R., Simmonds J., Vergnano S., Davis P., Kadambari S.

This study describes a cluster of severe parvovirus B19-associated myocarditis cases in children across England in the context of an increase in circulating virus. Cases were identified across 3 large children's centers. Eight cases presented from 1 January 2019 to 31 December 2023 as compared with 19 from 1 January 2024 to 31 August 2024. Almost all (n = 25, 93%) required intensive care, and 24 (88%) received inotropes and 4 (15%) extracorporeal membrane oxygenation. Myocarditis appears to be temporally associated and a late sequela of parvovirus B19, resulting in high rates of intensive care unit admission. Testing with serology and blood polymerase chain reaction should be part of a syndromic screen for all children with severe myocarditis.

Severe Parvovirus B19-Associated Myocarditis in Children in the Post-COVID-19 Era: A Multicenter Observational Cohort Study.

Russell N., Hatcher J., Best T., Breuer J., Charlesworth J., Muir P., Vipond B., Paulus S., Saxena R., Simmonds J., Vergnano S., Davis P., Kadambari S.

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