Haemophilus influenzae type b (Hib) is now recognized as an important pathogen in Asia. To evaluate disease susceptibility, and as a marker of Hib transmission before routine immunization was introduced in Kathmandu, 71 participants aged 7 months-77 years were recruited and 15 cord blood samples were collected for analysis of anti-polyribosylribitol phosphate antibody levels by enzyme-linked immunosorbent assay. Only 20% of children under 5 years old had levels considered protective (>0.15 µg/ml), rising to 83% of 15-54 year-olds. Prior to introduction of Hib vaccine in Kathmandu, the majority of young children were susceptible to disease.

Original publication

DOI

10.1371/journal.pone.0085055

Type

Journal

PLoS One

Publication Date

2014

Volume

9

Keywords

Adolescent, Adult, Aged, Antibodies, Bacterial, Bacterial Capsules, Child, Child, Preschool, Enzyme-Linked Immunosorbent Assay, Haemophilus Infections, Haemophilus Vaccines, Haemophilus influenzae type b, Host-Pathogen Interactions, Humans, Immunization Programs, Infant, Middle Aged, Nepal, Polysaccharides, Polysaccharides, Bacterial, Seroepidemiologic Studies, Vaccination, Young Adult