Differences in Immunization Site Pain in Toddlers Vaccinated with Either the 10- or the 13-Valent Pneumococcal Conjugate Vaccine.
Trück J., Kelly S., Jawad S., Snape MD., Voysey M., Pollard AJ.
We investigated immediate immunization pain in 12-month-old children randomized to receive a booster dose of either the 10- (PCV-10) or the 13-valent (PCV-13) pneumococcal conjugate vaccine. Pain was assessed using validated pain assessment tools and crying time. PCV-13 recipients had significantly higher scores on the observer-rated modified behavioral pain scale than did those receiving PCV-10, but the differences were small.Clinical trial registration at Clinicaltrials.gov (NCT01443416).