Declining Antibody Affinity Over Time After Human Vaccination With a Plasmodium falciparum Merozoite Vaccine Candidate.

Persson KEM., Horton JL., Kurtovic L., McCarthy JS., Anders RF., Beeson JG.

UNLABELLED: Maintaining high-affinity antibodies after vaccination may be important for long-lasting immunity to malaria, but data on induction and kinetics of affinity is lacking. In a phase 1 malaria vaccine trial, antibody affinity increased following a second vaccination but declined substantially over 12 months, suggesting poor maintenance of high-affinity antibodies. CLINICAL TRIALS REGISTRATION: Australian New Zealand Clinical Trials Registry ACTRN12607000552482.

DOI

10.1093/infdis/jiae259

Type

Journal article

Publication Date

2024-09-23T00:00:00+00:00

Volume

230

Pages

e753 - e757

Keywords

affinity maintenance, antibody, antibody affinity, malaria, malaria vaccine, Humans, Malaria Vaccines, Plasmodium falciparum, Malaria, Falciparum, Antibodies, Protozoan, Antibody Affinity, Merozoites, Adult, Vaccination, Male, Female, Young Adult, Australia, Adolescent

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