Associate Professor in Paediatrics and Vaccinology
- BRC Consultant in Paediatrics and Vaccinology
Matthew Snape, MBBS FRCPCH MD, is an Associate Professor in General Paediatrics and Vaccinology at the Oxford Vaccine Group, University of Oxford Department of Paediatrics and the NIHR Oxford Biomedical Research Council. He is also a Jenner Investigator and works as a General Paediatrician at the Children’s Hospital Oxford, Oxford University Hospitals NHS Trust.
Assoc. Prof. Snape's principal areas of research relate to vaccines against meningococcal, pneumococcal, influenza, RSV and Ebola virus disease. In 2014/2015 he was the lead investigator on a 'first in human' phase 1 study of a candidate ebola vaccine, providing data crucial to the planning of subsequent studies in West Africa. He is currently the Chief Investigator of the 'Be on the TEAM' study enrolling 24 000 Year 12 students to evaluate the impact of immunisation with group B meningococcal vaccines on pharyngeal carriage of meningococcus, and is the Director of the National Immunisation Schedule Evaluation Consortium (NISEC), both of which are NIHR funded. Other projects include leading on the instigation of the Global Platform for Prevention of Autoimmune Diabetes (GPPAD) in the UK, acting as a Chief or Principal Investigator on clinical trials of multiple RSV vaccine candidates and acting as the Chief Investigator on the ‘What’s the STORY’ study evaluating rates of COVID-19 infection in children.
Assoc. Prof. Snape graduated from the University of Melbourne in 1993 and completed his basic paediatric training at the Royal Children’s Hospital, Melbourne before continuing his training at St Mary’s Hospital, London. While working in the Paediatric Intensive Care Unit at St Mary’s hospital he became interested in the prevention of invasive meningococcal disease by immunisation, and on completion of his clinical training took up a post as a research fellow (later Clinical Lecturer) at the Oxford Vaccine Group, University of Oxford. While here he completed his post- graduate Doctor of Medicine (MD) degree, awarded by the University of Melbourne in 2009. He has been employed as a Consultant in General Paediatrics and Vaccinology since 2009 and was appointed an Associate Professor in 2018.
Assoc. Prof. Snape was acknowledged as an NIHR Clinical Research Network ‘Leading Commercial Principal Investigator’ in 2015 by Dame Sally Davis, Chief Medical Office, an exceptional Principal Investigator by the Thames Valley Clinical Research Network in 2016 and received a Vice Chancellor's award for Public Engagement in Research in 2016. He has published over 100 manuscripts relating to immunisation and is a member of the Meningitis Research Foundation's Medical Advisory Group.
AZD1222/ChAdOx1 nCoV-19 vaccination induces a polyfunctional spike protein-specific Th1 response with a diverse TCR repertoire.
Swanson PA. et al, (2021), Science translational medicine, eabj7211 - eabj7211
Reactogenicity and immunogenicity after a late second dose or a third dose of ChAdOx1 nCoV-19 in the UK: a substudy of two randomised controlled trials (COV001 and COV002)
EWER K. et al, (2021), The Lancet
Distinct patterns of within-host virus populations between two subgroups of human respiratory syncytial virus.
Lin G-L. et al, (2021), Nat Commun, 12
Safety and immunogenicity of heterologous versus homologous prime-boost schedules with an adenoviral vectored and mRNA COVID-19 vaccine (Com-COV): a single-blind, randomised, non-inferiority trial.
Liu X. et al, (2021), Lancet
Preventing type 1 diabetes in childhood.
Dayan CM. et al, (2021), Science, 373, 506 - 510