Compromised CD4:CD8 ratio recovery in people living with HIV aged over 50 years: an observational study.
Francis-Morris A., Mackie NE., Eliahoo J., Ramzan F., Fidler S., Pollock KM.
OBJECTIVES: Persistent CD4:CD8 ratio inversion ( 900 cells/μL) decreased. The median pre-ART CD4:CD8 ratio was 0.41 (IQR 0.24-0.63), and recovery (≥ 1) occurred in 274 of 876 patients (31.3%). Pre- and post-ART CD4:CD8 ratios were lower in those aged > 50 years compared with young adults aged 18-30 years (P 50 years) at HIV diagnosis was associated with persistent CD4:CD8 ratio inversion, whereas treatment of PHI was protective. These findings confirm the need for testing and early treatment of people aged > 50 years, and could be used in a risk management algorithm for enhanced surveillance.