� 2016 Elsevier Inc. All rights reserved. Today considerable effort is undertaken during vaccine development to identify and measure potential mechanisms of immunological protection. These proposed measurements are then validated by correlation with protection from disease after natural exposure or passive protection, or alternatively related to vaccine efficacy or effectiveness endpoints. The desire to identify correlates of protection, especially early in the development of a vaccine, is more than scientific curiosity. The importance of correlates of protection is evident by the reduction of the financial risk associated with clinical development of new vaccines, support of the use of a vaccine in new populations, and the pivotal role in the assessment of the public health impact of vaccines.

Original publication





Book title

The Vaccine Book: Second Edition

Publication Date



121 - 149