Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

On November 20, 2017, the Typhoid Vaccine Acceleration Consortium (TyVAC) vaccinated the first of 20,000 children against typhoid, successfully launching a study to assess the impact of typhoid conjugate vaccines (TCVs) in preventing typhoid among children in Nepal.

Photo: Bill & Melinda Gates Foundation/Sam Reinders

This vaccination study is part of TyVAC’s effort to generate evidence on TCV impact, and accelerate the use of TCVs in countries with significant typhoid burden. The study in Nepal is taking place over two years, and the results will inform future country introduction plans for the TCV. Successful introduction of the TCV in low-income countries that experience a high burden of typhoid, like Nepal, could potentially prevent many cases and deaths among children every year.

Before the study launched, project staff conducted extensive community outreach in the Kathmandu Valley, where it is taking place. Community support for the study is essential and activities ranged from staff going door-to-door and visiting local mothers’ groups to meetings with the district’s Public Health Division, mayor and other locally elected representatives. The project staff were also trained on a number of different topics, including cold chain management, vaccination administration, informed consent, data management and more, reflecting the effort that it takes to vaccinate 20,000 children in only three months.

The TCV being used in the study is the recently prequalified Typbar-TCV®. This new TCV has several advantages over earlier typhoid vaccines, including the potential ability to provide longer-lasting protection. It also requires fewer doses, and can be administered to children younger than two years of age, making it the first-ever typhoid vaccine to be approved for this age group. This is especially important, as children and adolescents younger than 15 years of age are disproportionately impacted by typhoid. As TyVAC continues to collect data, this will help gather evidence on how effective TCV is at preventing typhoid and potentially saving many children’s lives.

View more details in the photo story here - written by Rachel Colin-Jones.

 

Similar stories

From running COVID-19 trials to researching respiratory diseases - Daniela Ferreira discusses her journey from Brazil to Oxford

Daniela Ferreira, Professor of Mucosal Immunity and Infection at the Oxford Vaccine Group, Department of Paediatrics, has so much enthusiasm for her work on respiratory infections and vaccinology, you would be very hard-pressed not to want her to succeed

Oxford to work with Brazil to establish clinical research hub

The University of Oxford and Brazilian Ministry of Health have announced a joint initiative to set up a global health and clinical research unit in Brazil led by Professor Sue Ann Clemens CBE.

Phase I trial begins of new vaccine against the Plague

Researchers at the University of Oxford today launched a Phase 1 trial to test a new vaccine against plague.

Delayed second dose and third doses of the Oxford-AstraZeneca vaccine lead to heightened immune response

Research on the ChAdOx1 nCoV-19, also known as the Oxford-AstraZeneca vaccine, indicates that a long interval between first and second doses does not compromise the immune response after a late second dose.

Oxford University extends COVID-19 vaccine study to children

The University of Oxford, together with three partner sites in London, Southampton and Bristol, is to launch the first study to assess the safety and immune responses in children and young adults of the ChAdOx1 nCoV-19 coronavirus vaccine.

World Health Organization experts provide guidance on use of the Oxford vaccine

WHO SAGE says Oxford's coronavirus vaccine is safe and likely to be efficacious in older adults, and recommends its use in this age group.