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The Oxford Vaccine Group, part of University of Oxford, gave 99 volunteers a drink laced with live Salmonella Typhi bacteria a month after vaccinating them. Between 40% and 50% of the volunteers for the trial were students, Healthcare professionals were allowed to take part if they were not in patient-facing jobs or if they were willing to take around 3-4 weeks off work to be infected
Invasive non-typhoidal Salmonella disease
Non-typhoidal Salmonellae are a group of bacteria that cause gastroenteritis and are found throughout the world. However, these bacteria can sometimes spread beyond the gut into the blood stream, causing invasive non-typhoidal Salmonella (iNTS) disease, a condition which disproportionately affects individuals with weak immune systems (e.g. due to malnutrition or HIV co-infection).