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A large field study of typhoid conjugate vaccine (TCV) in Nepal has shown a single dose to be safe and effective in reducing typhoid in children aged 9 months to <16 years in an endemic setting.
Invasive non-typhoidal Salmonella disease
Non-typhoidal Salmonellae are a group of bacteria that cause gastroenteritis and are found throughout the world. However, these bacteria can sometimes spread beyond the gut into the blood stream, causing invasive non-typhoidal Salmonella (iNTS) disease, a condition which disproportionately affects individuals with weak immune systems (e.g. due to malnutrition or HIV co-infection).