ReSET
A study exploring nasal bacteria
Help us learn about the leading cause of healthcare infections
The Oxford Vaccine Group is inviting volunteers aged 18–55 to take part in an important research study called ReSET.
Staphylococcus aureus (“Staph”) is a very common bacteria that lives harmlessly in the noses of about 3 in 10 healthy adults. In some people, however, it can cause infections – especially after surgery or in those who are more vulnerable. There is currently no vaccine against Staph, and it is getting more difficult to find antibiotics that work well.
This study aims to understand how Staph lives in the nose by placing a very small amount of the bacteria into the nose (called ‘challenge’) and studying how the body responds. This will help us understand why some people carry Staph more easily than others.
If you are 18–55 years old and in good health, you may be able to take part. The study involves between 10 and 20 clinic visits over about 2-4 months and 1 final follow-up phone call at 4 or 8 months, to check if you are well. You will be ‘challenged’ with the bacteria up to 2 times. You will receive a short decolonisation treatment before and after the challenge, and we will collect nasal samples and throat and skin swabs, as well as blood tests. You will also complete brief online symptom diaries and self-collect nasal samples at home.
You will be closely monitored by the study team and will be given a 24-hour telephone number, should you have concerns.
Taking part is voluntary, and you can withdraw at any time. Volunteers will receive up to £1300 as reimbursement for their time, travel, and inconvenience.
Find out more :
If you are interested in taking part complete the Prescreening Questionnaire :
Location
Oxford Vaccine Group, University of Oxford
Links
Programme
Correlates of Immunity – Artificial Intelligence (COI-AI)