Daniel O'Connor
BSc AFHEA MSc DPhil (OXON)
Associate Professor | Head of Bioinformatics
Daniel has both a wet-laboratory and bioinformatics background, his main research interests relate to the analysis of contemporary, high-dimensional datasets (e.g. genomic, transcriptomic, proteomic) to elucidate the molecular determinants of vaccine responses.
UTILISING THE SYSTEMS TOOLKIT TO ELUCIDATE THE MECHANISMS UNDERLYING RESPONSES TO INFANT IMMUNISATION
Vaccine responses and the persistence of vaccine-immunity vary considerably between individuals, this is particularly relevant in childhood, as infants generally have lower magnitude immune responses that wane more rapidly than adults. My research utilises contemporary methods, such as genome-wide genotyping and next-generation sequencing, to explore the mechanisms underlying immunological and physiological responses to childhood vaccinations.
Key publications
-
Human leukocyte antigen alleles associate with COVID-19 vaccine immunogenicity and risk of breakthrough infection.
Journal article
Mentzer AJ. et al, (2023), Nat Med, 29, 147 - 157
-
Molecular correlates of vaccine-induced protection against typhoid fever.
Journal article
Zhu H. et al, (2023), J Clin Invest, 133
-
Gene expression profiling reveals insights into infant immunological and febrile responses to group B meningococcal vaccine.
Journal article
O'Connor D. et al, (2020), Mol Syst Biol, 16
-
Common Genetic Variations Associated with the Persistence of Immunity following Childhood Immunization
Journal article
O'Connor D. et al, (2019), Cell Reports
-
Multi-omics analysis reveals COVID-19 vaccine induced attenuation of inflammatory responses during breakthrough disease.
Journal article
Drury RE. et al, (2024), Nat Commun, 15
Recent publications
-
Inflammation of the nasal mucosa is associated with susceptibility to experimental pneumococcal challenge in older adults.
Journal article
Urban BC. et al, (2024), Mucosal Immunol
-
Multi-omics analysis reveals COVID-19 vaccine induced attenuation of inflammatory responses during breakthrough disease.
Journal article
Drury RE. et al, (2024), Nat Commun, 15
-
Children with perinatally acquired HIV exhibit distinct immune responses to 4CMenB vaccine.
Journal article
Cotugno N. et al, (2024), JCI Insight, 9
-
Targeted metagenomics reveals association between severity and pathogen co-detection in infants with respiratory syncytial virus.
Journal article
Lin G-L. et al, (2024), Nat Commun, 15
-
A Genome-Wide Association Study of Respiratory Syncytial Virus Infection Severity in Infants.
Journal article
Johnson M. et al, (2024), J Infect Dis, 229, S112 - S119