Homepage

Read about the Oxford Vaccine Centre’s COVID-19 vaccine trial.

Read about Oxford Vaccine Group's Com-Cov vaccine trial investigating different combinations of approved COVID-19 vaccines.

Coronavirus vaccination linked to substantial reduction in hospitalisation, real-world data suggests

The first study to describe the effects in real-world communities of the Oxford coronavirus vaccine has been reported in a pre-print publication today, showing a clear reduction in the risk of hospitalisation from COVID-19 amongst those who have received the vaccine.

Oxford University extends COVID-19 vaccine study to children

The University of Oxford, together with three partner sites in London, Southampton and Bristol, is to launch the first study to assess the safety and immune responses in children and young adults of the ChAdOx1 nCoV-19 coronavirus vaccine.

World Health Organization experts provide guidance on use of the Oxford vaccine

WHO SAGE says Oxford's coronavirus vaccine is safe and likely to be efficacious in older adults, and recommends its use in this age group.

Oxford leads first trial investigating dosing with alternating vaccines

The Oxford Vaccine Group is to lead the first trial to explore alternating different COVID-19 vaccines, to explore the potential for flexibility in delivery and look for clues as to how to increase the breadth of protection against new virus strains.

Trial participant having a blood sample taken.

Oxford scientists: how we developed our COVID-19 vaccine in record time

The pandemic is only a year old, but we already have multiple vaccines available to fight COVID-19 – including the vaccine developed by the team at the University of Oxford. Tonia Thomas and Rachel Colin-Jones describe the process that led to this scientific success.

Take part in a clinical trial – see a list of all the trials we are currently recruiting to.

Child being vaccinated

Non-COVID research statement

The Oxford Vaccine Group will be continuing with some of our non-COVID research, particularly our paediatric studies, during the COVID-19 pandemic. This is because as part of these studies we give babies their routine primary immunisations on behalf of their GPs. This reduces the administrative burden on the NHS, allowing them to free up capacity and prioritise their workload to be focused on doing what is necessary to manage the response to the COVID-19 pandemic. The participants also benefit from having the vaccines in the safety of their homes or a convenient location.

Vaccine Knowledge

The Vaccine Knowledge Project aims to be a source of independent information about vaccines and infectious diseases.

See more

Research

Vaccines are a key component of global health policy and are essential in the defence of the health of young children. Our research focuses on the development and evaluation of new and improved vaccines.

Explore

Events and Training

We are committed to providing high quality education and training, together with research updates for medical professionals and all those involved in the area of vaccines and paediatric and adult infectious diseases.

Learn

Get involved

There are a number of ways in which you can get involved in our research, inform our research and find out more about our work. To find out more about any of these options, follow the link below.

Participate

Latest publications

The antigenic anatomy of SARS-CoV-2 receptor binding domain
Journal article

GUPTA S. et al, (2021), Cell
Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials.
Journal article

Voysey M. et al, (2021), Lancet
Procalcitonin, C-reactive protein, neutrophil gelatinase-associated lipocalin, resistin and the APTT waveform for the early diagnosis of serious bacterial infection and prediction of outcome in critically ill children
Journal article

Nielsen MJ. et al, (2021), PLOS ONE, 16, e0246027 - e0246027
Changes in epigenetic profiles throughout early childhood and their relationship to the response to pneumococcal vaccination
Journal article

Pischedda S. et al, (2021), Clinical Epigenetics, 13
Vi-specific serological correlates of protection for typhoid fever.
Journal article

Jin C. et al, (2021), The Journal of experimental medicine, 218

Upcoming events

IIC 2021 - The Virtual Edition. Hot Topics In Infection And Immunity In Children

Friday, 02 July 2021

IIC - The ESPID-Oxford Course is a residential training course covering topics in paediatric infection for paediatric infectious diseases trainees and trainers, and for all those who manage children with infections. This will be the 18th edition of the course. After having to cancel last year's IIC, the Organising Committee have decided to hold IIC 2021 as a one-day, intensive virtual event.

How does herd immunity work?

‘Herd immunity’ or 'herd protection' gives protection to vulnerable people such as newborn babies, elderly people and those who are too sick to be vaccinated.

How to make a vaccine in record time

Vaccines usually take decades to develop – so how is Oxford University's ChAdOx1 nCoV-1 vaccine trial moving so quickly? It comes down to careful planning, extraordinary logistics and a whole lot of help from partners around the world.